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The pilot study, led by senior authors Henrik Zetterberg of the University of Gothenburg and Alexander Choukér of the Ludwig-Maximilians University Munich , followed five Russian cosmonauts onboard the International Space Station. By tracking the concentration of brain-specific proteins before and after the space mission, the researchers concluded that long-term spaceflight presents a slight, but lasting, threat to neurological health. The results may have ramifications for future space missions, including manned journeys to Mars. “This [brain cell damage] must be explored further and prevented if space travel is to become more common in the future,” says Zetterberg. Blood-based biomarkers expose brain injuries The cosmonauts – five men with an average age of 49 – spent almost half a year in space. The researchers took blood samples from the participants both pre-flight (20 days before on front page launch) and post-flight (one day, one week and three weeks after landing). Using single molecule array testing, a technique sensitive enough to detect proteins at the femtogram per millilitre level, they studied the concentration at each time point of five blood-based brain biomarkers: neurofilament light (NfL), glial fibrillary acidic protein (GFAP), total tau and the amyloid-beta proteins Aβ40 and Aβ42. These proteins shed light on the structural integrity of brain tissue. Increased levels of NfL in the cerebrospinal fluid or blood, for example, are associated with damage to the brain’s connecting fibres, the axons.

https://physicsworld.com/a/blood-tests-reveal-brain-damage-following-long-term-spaceflight/

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